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Zonisamide Weight Loss | Does It Truly Lead To Weight Loss?

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Zonisamide Weight Loss

Zonisamide Weight Loss | Does It Truly Lead To Weight Loss?: When paired with regular nutritional counseling, a prescription medicine initially created to treat epilepsy could help obese adults lose weight, experts suggest.

The latest trial found that patients that took 400 milligrams of a anti-seizure medicine zonisamide. That every day for a year drop an average of 7.5 pounds as much as those assigned to diet and lifestyle changes alone.

Zonisamide Weight Loss | Does It Truly Lead To Weight Loss?

Zonisamide Weight Loss

Limit Their Weight Gain By Diet And Lifestyle Changes

They did, however, experience more adverse effects than those who did not take the medicine at all. Dr. Kishore Gadde, head of the Obesity Clinical Research Center at Duke University Medical Center in Durham, N.C., said.

“The aim was to determine if more weight loss could achieve if we gave decent quality lifestyle intervention, largely food counseling, along with this drug.

Gadde replied, “Or the answer was yes.”

The study, which was financed by the National Institutes of Health, was published online on October 15 inside the journal Archive of Internal Medicine.

Nonsurgical choices for obese women and men who are unable to control. Also, their weight via diet and lifestyle modifications are limited, according to the study’s authors. Only a few prescription drugs, notably orlistat and lorcaserin hydrochloride, are approve in the United States the long-term management of obesity.

Gadde and his colleagues wanted to find out more about zonisamide (Zonegran) after a 16-week study they did in 2003 suggested that 400 milligrams a day could be an alternative.

The Highest Zonisamide Dose Users Dropped The Most Weight

The study team put more than 200 overweight men and women into one of 3 groups at random between 2006 and 2011. One group got 200 mg of zonisamide every day. Also, another team received 400 mg of zonisamide every day, and the third group got a fake pill.

The average age of the people who took part was 43, as well as their average BMI was nearly 38. BMI is a way to figure out how fat your body is based on your height and weight. If your BMI is over 30, you are considered obese. None had diabetes.

All of the people in the study stuck to their treatment protocol for a year. Throughout that time, they all got “not intensive” nutrition counseling once a month, which Gadde said helped them cut their as a whole caloric intake.

Those who took a higher dose of zonisamide lost the most weight overall, while those who took a lower dose didn’t lose much more weight than those who took a placebo.

Even though almost 55% of those who took the higher-dose medication lost at least 5% of their weight before the study, only 34% of those who took the lower-dose medication and 31% of those who didn’t take any medication did the same.

But patients in both groups were more likely to have side effects like diarrhea, headaches, tiredness, nausea and vomiting, trouble concentrating and remembering, anxiety, and depression.

They Concluded That A Greater Dose Of Zonisamide May Aid In Weight Loss

The authors said that these kinds of side effects tend to be “mild.” They came to the conclusion that the higher dose of zonisamide might help people lose weight, but they told doctors to great care weigh the pros & cons for each patient.

Gadde warned, “There is no one medicine that will cure obesity.” The most important thing to remember is that even though we use a mathematical formula to diagnose obesity (a BMI of 30 or higher). Also, the cause of obesity can different for each person.

He believes that psychological or lifestyle variables may play a role. “However, for roughly a third [of patients], physiologic concerns are at work. Such as difficulty receiving satiety signals from of the gut toward the brain. Also, which measures how much energy you’ve consumed,” he explained. “And medication can benefit those people.”

Lona Sandon, a registered dietitian and clinical nutrition assistant professor. At the University of Texas Southwestern Medical Clinic in Dallas, agreed. Sandon advises caution when utilizing a medicine that was approve for one ailment for another.

“However, for many people, this type of medicine could absolutely be of enormous assistance. ” She said, “by doing something that supports the management of the these appetite hormone and the regulatory route.”

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